LDN-193189；4-[6-(4-(哌嗪-1-基)苯基]吡唑并[1,5-a]嘧啶-3-基)喹啉；1062368-24-4

Formula:C25H22N6

Molecular Weight：406.48

Appearance：Light yellow to yellow powder

Purity：98+%

LDN-193189 (DM3189) is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β