尼达尼布乙基磺酸盐;(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐

Product Name:Nintedanib Ethanesulfonate Salt
 
CAS No.:656247-18-6
 
Synonym:Nintedanib(ethanesulfonic acid);BIBF 1120 esylate;Nintedanib esylate;BIBF-1120 esylate
 
Chemical name:(3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid methyl ester ethanesulfonate
 
Molecular formula:C33H39N5O7S
 
Molecular weight:649.76
  
Purity(HPLC):≥99%

Biological Activity:
Nintedanib Ethanesulfonate Salt is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β. In all tumor models tested thus far, including human tumor xenografts growing in nude mice and a syngeneic rat tumor model, Nintedanib Ethanesulfonate Salt is highly active at well-tolerated doses (25-100 mg/kg daily p.o.).