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现货供应对照品CHIR 99021(CT 99021)
产品型号：C13462
英文简称：
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Chemical Name: 6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile
别名：CHIR 99021(CT 99021)
分子式：C22H18Cl2N8
分子量：465.35
纯度：>98%
CAS：252917-06-9
Biological Activity:
A cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). CHIR99021 exhibits little to no activity toward 46 other enzymes (IC50>8.8 µM against 20 kinases and Kι ≥5 µM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 µM). CHIR99021 is orally available and is shown to effectively improve glucose metabolism in both murine and rat type 2 diabetes models in vivo.