所在位置: 首页 > 化合物对照品/标准品 > 癌症(肿瘤)研究系列
现货供应NVP-TAE684-TAE 684 对照品
产品型号：C13950
英文简称：
产品咨询
咨询电话：021-20908456
产品详情
Synonym: NVP-TAE 684
Chemical Name: 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-Pyrimidinediamine
Molecular Formula:  C30H40ClN7O3S
Molecular Weight:  614.22
Appearance: Yellow solid
Purity: >99%
CAS No.： 761439-42-3
Biological Activity:
A highly potent and selective smallmolecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM.NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.In vivo, NVP-TAE684 suppressed lymphomagenesis in two independent models of ALK-positive ALCL and induced regression of established Karpas-299 lymphomas.