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现货供应Entinostat/恩替诺特
产品型号：C13619
英文简称：
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别名： N-[[4-[[(2-氨基苯基)氨基]甲酰]苯基]甲基]氨基甲酸 3-吡啶基甲基酯
化学名称：pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate;[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]- Carbamic acid 3-pyridinylmethyl ester
英文名：Entinostat(MS-275,SNDX-275)
分子式：C21H20N4O3
分子量： 376.41
外观： Yellow powder
溶解性： Soluble in ethanol, DMSO and DMF
纯度： >99%
CAS No： 209783-80-2
Biological Activity:
Entinostat is a synthetic benzamide derivative that inhibited partially purified human histone deacetylase (HDA) with an IC50 of 2 µM and induced hyperacetylation of nuclear histones in tumor cell lines.  Entinostat inhibited the proliferation of various human tumor cell lines such as A2780, Calu-3, HL-60, and K562 (IC50 values were 0.0415 µM, 0.195 µM, 0.212 µM, and 0.589 µM, respectively).  Entinostat also inhibited the growth of human tumor xenografts in nude mouse.  Saito, A., et al.  "A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors."
Entinostat inhibited the proliferation of human breast cancer cells by inducing the expression of transforming growth factor (TGF)-β type II receptor (TβRII) mRNA, but not TGF-beta type I receptor mRNA.  Lee, B.I., et al.  "MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells