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现货供应Rapamycin/雷帕霉素
产品型号：C14089
英文简称：
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别名：西罗莫司
化学名称：23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine
英文名：Rapamycin;Sirolimus
分子式：C51H79NO13
分子量：914.18
纯度： >99%
外观： Odorless, off-white to yellow crystalline powder
CAS No：53123-88-9
Biological Activity:
RAPA administration in two types of fully allogeneic BM transplantation (BMT) systems in which host T cells mediate the rejection of TCD BM grafts (DBAf1 transplanted into C57BLf6 and BALBfc transplanted into C57BLf6). In both instances, RAPA administration prevented the rejection of the donor graft, accelerated post-BMT hematopoietic recovery, and did not compromise recipient survival.
In vitro, rapamycin inhibited the proliferation of primary bone marrow cells induced by IL-3, GM-CSF, KL, or a complex mixture of factors present in cell-conditioned media. Rapamycin also inhibited the multiplication of colony-forming cells in suspension cultures containing IL-3 plus interleukin-1 (IL-1) or interleukin-11 (IL-11) plus KL.