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现货供应Vatalanib 2hcl/瓦他拉尼
产品型号：C14321
英文简称：
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别名：瓦他拉尼二盐酸盐; N-(4-氯苯基)-4-(4-吡啶甲基)-1-酞嗪胺二盐酸盐
化学名称：N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
英文名：Vatalanib dihydrochloride
分子式： C20H15ClN4.2(HCl)
分子量： 419.74
纯度： >99%
外观：White to off-white powder
CAS No： 212141-51-0
Biological Activity:
 
 
 
Vatalanib is a potent, selective, orally active inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-ß (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 µM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 µM)