雷公藤红素(Celastrol)，又名南蛇藤素，是存在于卫矛科植物雷公藤、南蛇藤等中的**活性成分。该化合物结构载于2006年5月份Cancer Research杂志封面，并证实南蛇藤素通过抑制蛋白酶体活性进而诱发癌细胞凋亡，是有效的蛋白酶体抑制剂，其显著抑制了裸鼠身上前列腺癌的增生。因此，在癌症的预防和**方面，南蛇藤素是具有巨大开发潜力的天然蛋白酶体。
CAS Number: 34157-83-0
Chemical Name:  (9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26 -trinoroleana-1(10),3,5,7-tertraen-29-oic acid
Molecular Weight: 450.6
Molecular Formula: C₂₉H₃₈O4
Purity: >98%,99% by HPLC.
Biological Activity:
A variety of natural products from plant sources, particularly flavonoids, have long been observed to have antioxidant activity with potential benefits for human health. Antioxidant triterpenes are less common. Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC₅₀ value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.